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X-ray velocimetry (XV Technology) is four-dimensional imaging (in three spatial dimensions, plus time) which uses the shift in the phase of an X-ray as it passes through an object. Phase shifts in X-rays are then enhanced at air-tissue interfaces. Therefore, the exact properties of the lung that make it impossible to image by other advanced imaging techniques actually make it ideal for XV Technology's phase-contrast imaging.
XV Technology's Lung Ventilation Analysis Software (XV LVAS) provides a novel, non-invasive way of understanding regional lung motion and airflow. It enables highly-detailed maps of both the patterns of lung motion and pulmonary function, with functional deficits detected through local (regional) differences in movement.
In preclinical studies, XV Technology has been used extensively to examine regional ventilation in disease models for Cystic Fibrosis, Acute Respiratory Distress Syndrome, chronic lung allograft dysfunction, Alpha-1 antitrypsin deficiency, and Lymphangioleiomyomatosis.