A major new multi-center study published in Respiratory Research (July 2025) demonstrates that 4DMedical’s X-ray Velocimetry Lung Ventilation Analysis Software (XV LVAS®) can reveal early and subtle forms of small airways disease that are often missed by standard tests like spirometry and CT scans. Researchers from Vanderbilt University, Johns Hopkins, University of Miami, and Alfred Hospital in Melbourne showed that XV technology identifies disease-specific and severity-specific biomarker patterns in chronic obstructive pulmonary disease (COPD) and deployment-related constrictive bronchiolitis (DR-CB)—even when conventional tests appear normal.

Using low-dose, free-breathing fluoroscopy, XV LVAS produces detailed, region-specific color maps of lung ventilation, offering actionable insights for optimized patient care and potentially reducing the need for invasive biopsy. The validated XV-based “4DH score” differentiated patients from controls and revealed unique biomarker signatures for each disease. Already cleared for clinical use in the U.S., this breakthrough imaging tool is now being evaluated in larger groups to transform respiratory diagnostics.

Read the full press release and access the study here.