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4DMedical

4DMedical is a global leader in innovative respiratory and cardiopulmonary imaging software. Using advanced, non-invasive CT imaging technology, our SaaS offerings provide non-invasive, regional and lobar quantitative lung function analysis for unparalleled insights into cardiopulmonary health. With a single CT lung scan, 4DMedical provides automated, quantitative analysis that equips radiologists with detailed insights to support ordering physicians in delivering optimal patient care.
 

View the entire 4DMedical portfolio.

What to Expect at RSNA 2025

CT:VQ™ and the 4DMedical Lung Health Imaging Panel: 
One modality. One department. Complete pulmonary imaging.

With the 4DMedical suite of products, a single CT scanning event in Radiology delivers quantified, actionable insights into cardiopulmonary function: ventilation, perfusion, and regional function quantification—through an automated, streamlined, PACS‑native workflow.

4DMedical CT:VQ™ Launch Reception

Monday, Dec 1
3:00–5:00 PM
South Hall, 1759

CT:VQ™ Offers the First and Only Ventilation & Perfusion Imaging from Your Existing Non-Contrast CT Scans

CT:VQ™ converts standard (non-contrast) CT scans into high-quality ventilation and perfusion datasets, comparable to SPECT V/Q studies, without nuclear imaging or tracers. It fills a critical healthcare gap by using prevalent CT infrastructure, enhancing access, efficiency, and patient flow. CT:VQ supports major clinical needs, like pulmonary hypertension and lung cancer planning, promising a new standard in lung function assessment and broad adoption.

Brief presentation, 3:30pm: Andreas Fouras, CEO, CTO

Monday, December 1  |  3:00–5:00pm  | 4DMedical, South Hall #1759

Expert Speaker Panel

Tuesday, Dec 2
6:30–7:30 am

Hyatt Regency, Chicago Convention Center

Power Breakfast: "CT:VQ™ Ventilation and Perfusion Imaging from Your Existing Non Contrast CT"

CT:VQ™ Breakfast with 4DMedical + Philips at RSNA. Hear expert radiologist and pulmonologist speakers discuss real cases, practical workflow, and how CT-based ventilation and perfusion can change decision-making across COPD, asthma, and post-PE care.

Monday, December 2  |  6:30–7:30am
McCormick Place, Hyatt Regency Ballroom C–D

Seats are limited—register now.

Groundbreaking Technologies

CT Cardiopulmonary Assessment

  • CT:VQ™analyzes non-contrast CT scans to deliver quantified regional ventilation and perfusion maps and metrics for radiologists to report to referring clinicians.

  • CT LVAS™ provides clinicians with new, detailed information on regional lung ventilation to assess unexplained shortness of breath

  • CAC™ enables fast, accurate, and automated assessment of coronary artery calcification from CT scans, streamlining cardiovascular risk evaluation and aiding in early detection of heart disease1

  • IQ-UIP™ uses AI to automatically identify Usual Interstitial Pneumonia on CT scans with expert-level accuracy, streamlining diagnosis and enabling faster, more accessible specialist referrals1

  • LDAf™ is a fully automated tool that maps and quantifies normal lung, air-trapping, and emphysema from a CT scan, providing clear visualization of COPD and other lung conditions1

  • LDAi™ delivers fully automated detection and quantification of emphysema-related lung changes from standard low-dose CT scans, supporting lung cancer screening and smoking cessation counseling with easy-to-understand LungMap™ reports1

  • PHA™ automatically measures and reports the RV/LV ratio from CTPA scans, enabling rapid and accurate assessment of potential ventricular dilation in pulmonary hypertension1

  • XV LVAS® is lung airflow imaging software that processes conventional fluoroscopy scans to provide rich, functional lung health details unavailable via other modalities

In the News

4DMedical’s CT:VQ™ Receives FDA 510(k) Clearance; First-and-Only CT- based VQ Technology

Medicare reimbursement unlocks nationwide access to non-contrast ventilation–perfusion imaging from routine chest CT

4DMedical, a leader in advanced respiratory imaging, announces U.S. Food and Drug Administration (FDA) 510(k) clearance for CT:VQ™, the world’s first and only non-contrast, ventilation–perfusion (VQ) imaging solution. In parallel, the U.S. Centers for Medicare & Medicaid Services (CMS) has confirmed reimbursement for CT:VQ™ under Category III CPT codes; this payment is in addition to existing reimbursement for the underlying chest CT. CT:VQ converts standard, non‑contrast chest CTs into quantitative, lobar ventilation (V) and perfusion (Q) maps. Delivered as software‑as‑a‑service, it integrates directly with routine radiology workflows (DICOM-based, PACS reporting) and leverages the U.S. installed base of approximately 14,500 CT scanners, bringing functional lung imaging to sites without nuclear medicine capacity.

IQ-UIP: Addressing the Challenge of UIP—and IPF Diagnosis: A Conversation with Dr. Chung

Early identification of Usual Interstitial Pneumonia (UIP) and diagnosis of Idiopathic Pulmonary Fibrosis (IPF) remains a significant challenge in pulmonary medicine. Despite advances in imaging and clinical awareness, the process still requires specialized training and experience that isn’t always readily available—especially in non-urban or resource-limited healthcare settings. This gap can delay diagnosis which critically impacts patient outcomes.

In a recent interview hosted by Brian Casey, editor at The Imaging Wire, Dr. Chung, a leading thoracic radiologist, offers valuable perspective on the complexities associated with UIP identification and the essential role of expert interpretation/automated IQ-UIP1 to achieve accurate diagnoses.

AI-Driven CT Innovations from 4DMedical Transform COPD Diagnosis and Patient Care

As COPD continues to grow as a global health burden—predicted by the World Health Organization (WHO) to become the third leading cause of death by 2030—innovative AI-driven medical imaging technologies are rapidly advancing diagnosis, staging, and treatment. In a recent Radiology Today article, “Breathing Room,” writer Beth W. Orenstein explores how clinicians are increasingly relying on advanced CT imaging solutions that overcome the limitations of traditional lung function testing methods such as spirometry, which can be uncomfortable and challenging for patients, particularly elderly and those with impaired lung capacity.

Resource Center

New Research

Use of quantitative CT chest imaging to derive and assess a radiographic phenotype of deployment-related constrictive bronchiolitis

This study used chest CT scans taken during a full inhale and a full exhale to build a noninvasive “fingerprint” of deployment-related constrictive bronchiolitis, based on biopsy-confirmed cases versus healthy people, while accounting for age, sex, body size, and smoking. The team created a score (a DRCB Probability Index) that separated patients from healthy controls with high accuracy. When applied to symptomatic veterans without biopsies, 10 of 71 scored high; these individuals had more signs of small-airway problems on specialized breathing tests, CT signs of thicker airway walls and less efficient overall lung ventilation, and they reported worse immediate effects from burn pit smoke and sand/dust—despite mostly normal standard spirometry. The findings suggest computer-based CT analysis could help identify this condition without surgery.

Case Study

Automated Case-Finding—Identifying and Re‑Engaging At‑Risk Emphysema Patients with Zero-Click Workflows Emphysema and COPD are underdiagnosed in up to 50% of patients, and often not identified until advanced stages. For these patients, options like Bronchoscopic Lung Volume Reduction (BLVR) or Lung Volume Reduction Surgery (LVRS) can have a significantly positive impact on a patient’s quality of life. B4 Symptoms, in collaboration with Lahey Hospital and Medical Center, a B4-sponsored pilot site, initiated a comprehensive screening program using 4DMedical’s advanced imaging analysis software, based on Imbio1 Technology. This program aims to identify patients who could benefit from BLVR and LVRS therapies for advanced emphysema.  

Clinical Publications

1Imbio, a fully owned subsidiary of 4DMedical, is the legal manufacturer of CAC, LDA, PHA, IQ-UIP.

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