A: Application: Studies that apply 4DMedical technologies to specific indications

T: Direct Technology: Publications describing 4DMedical technologies

B: Base Technology: Publications describing the core technological platform that 4DMedical is built upon

R: Review/Editorial publications

1. Samarage, C. R. et al. Contrast Free Angiography of the Pulmonary Vasculature. in B96. NEW POWER GENERATION: CELLS, SEX HORMONES AND IMAGING IN PULMONARY VASCULAR DISEASE A4660–A4660 (American Thoracic Society, 2017). T

2. Kim, E. H. et al. Novel Analysis of 4DCT Imaging Quantifies Progressive Increases in Anatomic Dead Space During Mechanical Ventilation in Mice. Journal of Applied Physiology jap.00903.2016 (2017). A

3. Fouras, A. et al. A Motion Field Algorithm for Interfractional 4D Tumor Tracking. International Journal of Radiation Oncology*Biology*Physics 99, E707 (2017). T

4. Dubsky, S. et al. Assessment of airway response distribution and paradoxical airway dilation in mice during methacholine challenge. Journal of Applied Physiology jap.00476.2016 (2016). A

5. Hoarau, Y. et al. Flow and Particles Deposition in Rabbit and Rat Airways Under Realistic Inflow Rate. in Advances in Fluid-Structure Interaction 133, 193–204 (Springer International Publishing, 2016). B

6. Thurgood, J. et al. Imaging lung tissue oscillations using high-speed X-ray velocimetry. Journal of synchrotron radiation 23, (2016). B

7. te Pas, A. B. et al. Optimizing lung aeration at birth using a sustained inflation and positive pressure ventilation in preterm rabbits. Pediatric research (2016). A

8. Stahr, C. S. et al. Quantification of heterogeneity in lung disease with image-based pulmonary function testing. Scientific Reports 6, (2016). A/T

9. Macindoe, D., Kitchen, M. J., Irvine, S. C., Fouras, A. & Morgan, K. S. Requirements for dynamical differential phase contrast x-ray imaging with a laboratory source. Phys. Med. Biol. 61, 8720 (2016). B

10. Samarage, C. R. et al. Technical Note: Contrast free angiography of the pulmonary vasculature in live mice using a laboratory x-ray source. Medical Physics 43, 6017–6023 (2016). T

11. Kitchen, M. J. et al. X-ray specks: low dose in vivo imaging of lung structure and function. Physics in Medicine and Biology 60, 7259–7276 (2015). A

12. Lang, J. A. R. et al. Increase in pulmonary blood flow at birth: role of oxygen and lung aeration. The Journal of Physiology 594, 1389–1398 (2015). A

13. Fouras, A. & Dubsky, S. The Role of Functional Lung Imaging in the Improvement of Pulmonary Drug Delivery. in Pulmonary Drug Delivery: Advances and Challenges 19–34 (2015). R

14. Murrie, R. P. et al. Live small-animal X-ray lung velocimetry and lung micro-tomography at the Australian Synchrotron Imaging and Medical Beamline. Journal of Synchrotron Radiation 22, 1049–1055 (2015). B

15. Murrie, R. P., Paganin, D. M., Fouras, A. & Morgan, K. S. Phase contrast x-ray velocimetry of small animal lungs: optimising imaging rates. Biomed Opt Express 7, 79–92 (2015). B

16. Dubsky, S. & Fouras, A. Imaging regional lung function: A critical tool for developing inhaled antimicrobial therapies. Advanced Drug Delivery Reviews 85, 100–109 (2015). R

17. Donnelley, M. et al. Tracking extended mucociliary transport activity of individual deposited particles: longitudinal synchrotron X-ray imaging in live mice. Journal of Synchrotron Radiation 21, 768–773 (2014). A

18. Lang, J. A. R. et al. Ventilation/perfusion mismatch during lung aeration at birth. Journal of Applied Physiology 117, 535–543 (2014). A

19. Dubsky, S., Thurgood, J., Henon, Y. & Fouras, A. A Low Dose, High Spatio-Temporal Resolution System For Real-Time Four-Dimensional Lung Function Imaging. in C36. IMAGING AND THE LUNG: A RAPIDLY EVOLVING FIELD A4316–A4316 (American Thoracic Society, 2014). T

20. Kitchen, M. J. et al. Changes in Positive End-Expiratory Pressure Alter the Distribution of Ventilation within the Lung Immediately after Birth in Newborn Rabbits. PLoS ONE 9, e93391 (2014). A

21. Murrie, R. P. et al. Feasibility study of propagation-based phase-contrast X-ray lung imaging on the Imaging and Medical beamline at the Australian Synchrotron. Journal of Synchrotron Radiation 21, 430–445 (2014). T

22. Dubsky, S., Henon, Y., Jesudason, E., Fouras, A. & Thurgood, J. Heart-lung interactions: a vital source of gas mixing within the lungs. in D52. GAS EXCHANGE IN STEADY STATE, ALTITUDE, AND EXERCISE A6275–A6275 (Am Thoracic Soc, 2014). A

23. Morgan, K. S. et al. In vivo X-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis. American journal of respiratory and critical care medicine 190, 469–472 (2014). B

24. Donnelley, M. et al. Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo. Scientific Reports 4, (2014). A

25. Carnibella, R. P., Kitchen, M. J. & Fouras, A. Decoding the structure of granular and porous materials from speckled phase contrast X-ray images. Optics Express 21, 19153 (2013). B

26. Wheeler, K. et al. Establishing lung gas volumes at birth: interaction between positive end-expiratory pressures and tidal volumes in preterm rabbits. Pediatric Research 73, 734–741 (2013). A

27. Hooper, S. B. et al. Expired CO 2 levels indicate degree of lung aeration at birth. PLoS One 8, e70895 (2013). A

28. Leong, A. F. T. et al. High spatiotemporal resolution measurement of regional lung air volumes from 2D phase contrast x-ray images. Medical Physics 40, 041909 (2013). B

29. Morgan, K. S. et al. Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies. PLoS ONE 8, e55822 (2013). B

30. Ng, I., Paganin, D. M. & Fouras, A. Optimization of in-line phase contrast particle image velocimetry using a laboratory x-ray source. Journal of Applied Physics 112, 074701 (2012). B

31. Samarage, C. R., Carberry, J., Sheard, G. J. & Fouras, A. Polynomial element velocimetry (PEV): a technique for continuous in-plane velocity and velocity gradient measurements for low Reynolds number flows. Measurement Science and Technology 23, 105304 (2012). B

32. Carnibella, R. P., Fouras, A. & Kitchen, M. J. Single-exposure dual-energy-subtraction X-ray imaging using a synchrotron source. Journal of Synchrotron Radiation 19, 954–959 (2012). B

33. Dubsky, S., Hooper, S. B., Siu, K. K. W. & Fouras, A. Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement. Journal of The Royal Society Interface 9, 2213–2224 (2012). T

34. Siew, M. L. et al. The role of lung inflation and sodium transport in airway liquid clearance during lung aeration in newborn rabbits. Pediatric Research 73, 443–449 (2012). A

35. Dubsky, S. et al. Computed tomographic X-ray velocimetry for simultaneous 3D measurement of velocity and geometry in opaque vessels. Experiments in Fluids 52, 543–554 (2012). T

36. Carnibella, R. P., Kitchen, M. J. & Fouras, A. Determining particle size distributions from a single projection image. Optics Express 20, 15962 (2012). B

37. Donnelley, M., Morgan, K. S., Siu, K. K. & Parsons, D. W. Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour. Journal of synchrotron radiation 19, 551–558 (2012). A

38. Xiong, T. et al. Flow and particles deposition in anatomically realistic airways. Computer Methods in Biomechanics and Biomedical Engineering 15, 56–58 (2012). B

39. Thurgood, J. et al. Functional Lung Imaging during HFV in Preterm Rabbits. PLoS ONE 7, e48122 (2012). A

40. Dubsky, S., Hooper, S. B., Siu, K. K. W. & Fouras, A. in vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. in Developments in X-Ray Tomography VIII (2012). T

41. Jamison, R. A. et al. Functional Imaging to Understand Biomechanics: A Critical Tool for the Study of Biology, Pathology and the Development of Pharmacological Solutions. Current Pharmaceutical Biotechnology 13, 2128–2140 (2012). R

42. Thurgood, J. et al. Mapping cardiogenic oscillations using synchrotron-based phase contrast CT imaging. in Developments in X-Ray Tomography VIII (2012). B

43. Samarage, C. R., Carberry, J., Hourigan, K. & Fouras, A. Optimisation of temporal averaging processes in PIV. Experiments in Fluids 52, 617–631 (2011). B

44. Siew, M. L. et al. Surfactant Increases the Uniformity of Lung Aeration at Birth in Ventilated Preterm Rabbits. Pediatric Research 70, 50–55 (2011). A

45. Nguyen, C. V., Carberry, J. & Fouras, A. Volumetric-correlation PIV to measure particle concentration and velocity of microflows. Experiments in Fluids 52, 663–677 (2011). B

46. Fouras, A. et al. Altered Lung Motion is a Sensitive Indicator of Regional Lung Disease. Annals of Biomedical Engineering 40, 1160–1169 (2011). A/T

47. Hooper, S. B. et al. Combined lung imaging and respiratory physiology research at SPring-8. Synchrotron Radiation News 24, 19–23 (2011). A

48. Higgins, S. P., Samarage, C. R., Paganin, D. M. & Fouras, A. Holographic correlation velocimetry. in Proc. 9th International Symposium on Particle Image Velocimetry (PIV 11) (2011). B

49. Irvine, S. C., Paganin, D. M., Jamison, R. A., Dubsky, S. & Fouras, A. Vector tomographic X-ray phase contrast velocimetry utilizing dynamic blood speckle. Optics Express 18, 2368 (2010). B

50. Kitchen, M. J. et al. A new design for high stability pressure-controlled ventilation for small animal lung imaging. Journal of Instrumentation 5, T02002 (2010). B

51. Dubsky, S. et al. Computed tomographic x-ray velocimetry. Applied Physics Letters 96, 023702 (2010). T

52. Nguyen, C. V., Fouras, A. & Carberry, J. Improvement of measurement accuracy in micro PIV by image overlapping. Experiments in Fluids 49, 701–712 (2010). B

53. Nguyen, C. V., Fouras, A. & Carberry, J. Image Overlapping to Improve Micro PIV Accuracy. in Proc. 8th International Symposium on Particle Image Velocimetry – PIV09 (2009). B

54. Siew, M. L. et al. Inspiration regulates the rate and temporal pattern of lung liquid clearance and lung aeration at birth. Journal of Applied Physiology 106, 1888–1895 (2009). A

55. Fouras, A. et al. The past, present, and future of x-ray technology for in vivo imaging of function and form. Journal of Applied Physics 105, 102009 (2009). R

56. Fouras, A. et al. In-vivo Synchrotron PIV for the measurement of airway motion. in Proc. 8th International Symposium on Particle Image Velocimetry — PIV09 (2009). B

57. Irvine, S. C., Paganin, D. M., Dubsky, S., Lewis, R. A. & Fouras, A. Phase retrieval for improved multi-dimensional velocimetric analysis of X-ray blood flow speckle patterns. in (2009). B

58. Siew, M. L. et al. Positive end-expiratory pressure enhances development of a functional residual capacity in preterm rabbits ventilated from birth. Journal of Applied Physiology 106, 1487–1493 (2009). A

59. Donnelley, M. et al. Real-time non-invasive detection of inhalable particulates delivered into live mouse airways. Journal of Synchrotron Radiation 16, 553–561 (2009). A

60. Fouras, A., Jacono, D. L., Nguyen, C. V. & Hourigan, K. Volumetric correlation PIV: a new technique for 3D velocity vector field measurement. Experiments in Fluids 47, 569–577 (2009). B

61. Fouras, A. et al. Engineering Imaging: Using particle image velocimetry to see physiology in a new light. Clinical and Experimental Pharmacology and Physiology 36, 238–247 (2009). R

62. Nesbitt, W. S. et al. A shear gradient–dependent platelet aggregation mechanism drives thrombus formation. Nature Medicine 15, 665–673 (2009). B

63. te Pas, A. B. et al. Effect of Sustained Inflation Length on Establishing Functional Residual Capacity at Birth in Ventilated Premature Rabbits. Pediatric Research 66, 295–300 (2009). A

67. Nguyen, C., Fouras, A. & Carberry, J. Control of the depth of correlation in micro-PIV using a novel post-processing method. in XXII ICTAM (2008). B

68. Kitchen, M. J. et al. Dynamic measures of regional lung air volume using phase contrast x-ray imaging. Physics in medicine and biology 53, 6065 (2008). A

69. Fouras, A., Dusting, J., Lewis, R. & Hourigan, K. Three-dimensional synchrotron x-ray particle image velocimetry. Journal of Applied Physics 102, 064916 (2007). T

70. Fouras, A., Jacono, D. L. & Hourigan, K. Target-free Stereo PIV: a novel technique with inherent error estimation and improved accuracy. Experiments in Fluids 44, 317–329 (2007). B

71. Fouras, A., Dusting, J. & Hourigan, K. A simple calibration technique for stereoscopic particle image velocimetry. Experiments in Fluids 42, 799–810 (2007). B

72. Fouras, A., Hourigan, K., Kawahashi, M. & Hirahara, H. An improved, free surface, topographic technique. J Vis9, 49–56 (2006). B

73. Fouras, A. & Soria, J. Accuracy of out-of-plane vorticity measurements derived from in-plane velocity field data. Experiments in Fluids25, 409–430 (1998). B

74. Dubsky, S., Thurgood, J., Fouras, A., R. Thompson, B. & Sheard, G. J. Cardiogenic Airflow in the Lung Revealed Using Synchrotron-Based Dynamic Lung Imaging. Scientific Reports8, (2018). A/T

75. Yen S, Preissner M, Bennett E, Dubsky S, Carnibella R, Murrie R, Fouras A, Dargaville PA, Zosky GR: Interaction between regional lung volumes and ventilator-induced lung injury in the normal and endotoxemic lung. Am J Physiol Lung Cell Mol Physiol 2020, 318(3):L494-L499.

76. Murrie RP, Werdiger F, Donnelley M, Lin YW, Carnibella RP, Samarage CR, Pinar I, Preissner M, Wang J, Li J et al: Real-time in vivo imaging of regional lung function in a mouse model of cystic fibrosis on a laboratory X-ray source. Sci Rep 2020, 10(1):447.

77. Yen S, Preissner M, Bennett E, Dubsky S, Carnibella R, O’Toole R, Roddam L, Jones H, Dargaville PA, Fouras A et al: The Link between Regional Tidal Stretch and Lung Injury during Mechanical Ventilation. Am J Respir Cell Mol Biol 2019, 60(5):569-577.

78. Preissner M, Murrie RP, Pinar I, Werdiger F, Carnibella RP, Zosky GR, Fouras A, Dubsky S: High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals. Phys Med Biol 2018, 63(8):08NT03.

79. Preissner M, Murrie RP, Bresee C, Carnibella RP, Fouras A, Weir EK, Dubsky S, Pinar IP, Jones HD: Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice. Physiol Rep 2018, 6(19):e13875.

80. Goonan GW, Fouras A, Dubsky S: Array-source X-ray velocimetry. Opt Express 2018, 26(2):935-950.

81. Flemmer AW, Thio M, Wallace MJ, Lee K, Kitchen MJ, Kerr L, Roehr CC, Fouras A, Carnibella R, Jani JC et al: Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion. Pediatr Res 2017, 82(3):536-543.