{"id":47854,"date":"2025-07-15T07:13:01","date_gmt":"2025-07-15T15:13:01","guid":{"rendered":"https:\/\/4dmedical.com\/us\/?p=47854"},"modified":"2025-07-15T07:13:03","modified_gmt":"2025-07-15T15:13:03","slug":"new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease","status":"publish","type":"post","link":"https:\/\/4dmedical.com\/us\/blog\/2025\/07\/15\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\/","title":{"rendered":"New Study Underscores XV Technology\u2019s Power to Detect Hidden Lung Disease"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A major new multi-center study published in <em><a href=\"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-025-03295-6\">Respiratory Research<\/a><\/em> (July 2025) demonstrates that 4DMedical\u2019s <a href=\"https:\/\/4dmedical.com\/us\/products\/software\/xv-lvas\/\">X-ray Velocimetry Lung Ventilation Analysis Software (XV LVAS\u00ae) <\/a>can reveal early and subtle forms of small airways disease that are often missed by standard tests like spirometry and CT scans. Researchers from Vanderbilt University, Johns Hopkins, University of Miami, and Alfred Hospital in Melbourne showed that XV technology identifies disease-specific and severity-specific biomarker patterns in chronic obstructive pulmonary disease (COPD) and deployment-related constrictive bronchiolitis (DR-CB)\u2014even when conventional tests appear normal.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Using low-dose, free-breathing fluoroscopy, XV LVAS produces detailed, region-specific color maps of lung ventilation, offering actionable insights for optimized patient care and potentially reducing the need for invasive biopsy. The validated XV-based \u201c4DH score\u201d differentiated patients from controls and revealed unique biomarker signatures for each disease. Already cleared for clinical use in the U.S., this breakthrough imaging tool is now being evaluated in larger groups to transform respiratory diagnostics.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Read the <a href=\"https:\/\/en.prnasia.com\/story\/archive\/4729927_AE29927_0?utm_source=cleartime-customer&amp;utm_medium=email\">full press release<\/a> and access the study <a href=\"https:\/\/doi.org\/10.1186\/s12931-025-03295-6\">here<\/a>.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A major new multi-center study published in Respiratory Research (July 2025) demonstrates that 4DMedical\u2019s X-ray Velocimetry Lung Ventilation Analysis Software (XV LVAS\u00ae) can reveal early and subtle forms of small airways disease that are often missed by standard tests like spirometry and CT scans. Researchers from Vanderbilt University, Johns Hopkins, University of Miami, and Alfred Hospital in Melbourne showed that XV technology identifies disease-specific and severity-specific biomarker patterns in chronic obstructive pulmonary disease (COPD) and deployment-related constrictive bronchiolitis (DR-CB)\u2014even when conventional tests appear normal.<\/p>\n","protected":false},"author":5,"featured_media":47855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[2],"tags":[71,72],"class_list":["post-47854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-pulmonology","tag-radiology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Study Underscores XV Technology\u2019s Power to Detect Hidden Lung Disease - 4DMedical US<\/title>\n<meta name=\"description\" content=\"A new peer-reviewed study published in Respiratory Research confirms that 4DMedical\u2019s CT Lung Ventilation Analysis Software (CT LVAS) provides results comparable to those of the gold standard PET method, as well as two additional research techniques for assessing regional lung function. The findings demonstrate a strong association and agreement between 4DMedical\u2019s CT LVAS and PET-ventilation at the lobar level and comparable correlation at the voxel level. Utilizing routine non-contrast CT scans, CT LVAS generates detailed regional ventilation information. This highlights CT LVAS as a safe and contrast-free modality for functional lung imaging, making it an ideal tool for assessing lung function across a range of respiratory conditions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/4dmedical.com\/us\/blog\/2025\/07\/15\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Study Underscores XV Technology\u2019s Power to Detect Hidden Lung Disease - 4DMedical US\" \/>\n<meta property=\"og:description\" content=\"A new peer-reviewed study published in Respiratory Research confirms that 4DMedical\u2019s CT Lung Ventilation Analysis Software (CT LVAS) provides results comparable to those of the gold standard PET method, as well as two additional research techniques for assessing regional lung function. The findings demonstrate a strong association and agreement between 4DMedical\u2019s CT LVAS and PET-ventilation at the lobar level and comparable correlation at the voxel level. Utilizing routine non-contrast CT scans, CT LVAS generates detailed regional ventilation information. This highlights CT LVAS as a safe and contrast-free modality for functional lung imaging, making it an ideal tool for assessing lung function across a range of respiratory conditions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/4dmedical.com\/us\/blog\/2025\/07\/15\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"4DMedical US\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-15T15:13:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-15T15:13:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/4dmedical.com\/us\/wp-content\/uploads\/2025\/07\/Veterans-Mosaic-1920x1080-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michelle Martin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michelle Martin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/\"},\"author\":{\"name\":\"Michelle Martin\",\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/#\\\/schema\\\/person\\\/dac6f29cd556fa750bdea707a0899844\"},\"headline\":\"New Study Underscores XV Technology\u2019s Power to Detect Hidden Lung Disease\",\"datePublished\":\"2025-07-15T15:13:01+00:00\",\"dateModified\":\"2025-07-15T15:13:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/\"},\"wordCount\":177,\"publisher\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2025\\\/07\\\/Veterans-Mosaic-1920x1080-1.jpg\",\"keywords\":[\"Pulmonology\",\"Radiology\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/\",\"url\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/\",\"name\":\"New Study Underscores XV Technology\u2019s Power to Detect Hidden Lung Disease - 4DMedical US\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/blog\\\/2025\\\/07\\\/15\\\/new-study-underscores-xv-technologys-power-to-detect-hidden-lung-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/4dmedical.com\\\/us\\\/wp-content\\\/uploads\\\/sites\\\/2\\\/2025\\\/07\\\/Veterans-Mosaic-1920x1080-1.jpg\",\"datePublished\":\"2025-07-15T15:13:01+00:00\",\"dateModified\":\"2025-07-15T15:13:03+00:00\",\"description\":\"A new peer-reviewed study published in Respiratory Research confirms that 4DMedical\u2019s CT Lung Ventilation Analysis Software (CT LVAS) provides results comparable to those of the gold standard PET method, as well as two additional research techniques for assessing regional lung function. 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