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CT:VQ®

Maximum CONTRAST. No INJECTIONS.

Non‑contrast ventilation and perfusion from standard chest CTs

CT:VQ® is the world’s first non‑contrast post‑processing technology that transforms routine, chest CTs into quantitative, lobar ventilation (V) and perfusion (Q) maps—without injected contrast or radioisotopes. Delivered via software-as-a-service, results are returned directly into the radiology workflow for interpretation alongside the source CT images.

CT:VQ is FDA-cleared.

Eligible for reimbursement in the US under Category III CPT codes.

Trial CT:VQ® Today
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Designed for you

  • Pulmonologists and Interventional Pulmonologists: Obtain regional V/Q to support PE workups, CTEPH assessment, regional detection of V/Q abnormalities, BLVR planning, pre‑op assessment, and longitudinal monitoring in a single-page report designed to support patient communication, alongside the radiology report.

  • Radiologists:  Add functional interpretation to non‑contrast chest CTs with structured, quantitative outputs delivered to PACS with DICOM Structured Reporting to minimize workflow while maximizing clinical benefits.

  • Hospital and Imaging Administrators: Expand access to V/Q imaging across existing CT infrastructure with no new hardware and streamlined scheduling. Reduce operating costs and gain reimbursement.

Key Advantages

    • No Injections: Non‑Contrast CT only—no IV access, no radioisotopes, no contrast agents.
    • Accessible at Scale: Runs on the approximately 14,500 CT scanners installed across the U.S.—bringing V/Q to sites without nuclear medicine capacity or where capacity is constrained.
    • Patient‑ and Operations‑Friendly: Single CT appointment; simplified scheduling; avoids contrast media, IV placement, and related consumables; supports review of prior CTs to help avoid repeat imaging. comparisons between lobe size, ventilation, perfusion, and total right–left lungs

Breakthrough Features

  • Color V and Q overlays registered to CT anatomy

  • Quantitative Metrics

  • Total Lung Volumes (inspiratory, expiratory, and delta)

  • Lobar Distribution: comparisons between lobe size, ventilation, perfusion, and total right–left lungs

The Non-Contrast CT:VQ® Value-Added Solution

4DMedical CT:VQ® - Value-Add to Routine Chest CTs
4DMedical CT:VQ® - Value-Add to Routine Chest CTs
4DMedical CT:VQ® - Report Highlights
4DMedical CT:VQ® - Report Highlights

CT:VQ®—Non‑contrast Functional Lung Imaging, No Injections

Add functional insights to routine chest CT using existing scanners and PACS—eliminating contrast agents and supporting broader, patient‑friendly access.

Clinical Evaluation

CT:VQ®

CT:VQ® was evaluated using three complementary approaches: Data on file, 4DMedical

1. Quantitative correlation with SPECT V/Q (standalone device performance)

Additional Analysis: CT:VQ® perfusion heterogeneity metrics showed a stronger association with DLCO than comparable SPECT measures in the submission dataset (r²: 0.557 vs 0.380).

 

2. Reader performance study

        • Expert radiologists and nuclear medicine physicians graded regional function on CT:VQ® and SPECT V/Q using a standardized 5‑point scale.
        • Agreement with SPECT V/Q was rated good to excellent across all lung zones.
        • Kendall’s tau by zone (all readers): 0.702–0.765, exceeding the pre-specified 0.40 target for the submission.

 

3. Case‑based review

      • Illustrative cases demonstrated clinical interpretability across multiple conditions, highlighting areas of agreement and explaining discrepancies (e.g., SPECT ventilation limited by radiotracer deposition artifacts).

Get Started

  • Request a clinical demo and sample report
  • Submit a test case from your PACS
  • Plan a pilot across your CT fleet

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