4DMEDICAL FORMERLY KNOWN AS 4Dx
As the COVID-19 pandemic progresses, our knowledge of the disease and its threat to the respiratory system have been evolving rapidly. The prevalence of Acute Respiratory Distress Syndrome (ARDS) in severe, life-threatening cases of COVID-19 is now well-documented, and it is also evident that COVID-19 may lead to both short and long-term deterioration in patient’s lung function.
XV Technology can play an important role in detecting, mapping and quantifying any loss or improvement of lung function in COVID-19 patients. 4Dx Technology has been applied in preclinical ARDS studies for several years, demonstrating that regional lung ventilation abnormalities associated with ARDS can be identified with high sensitivity1–3. XV Technology has been demonstrated to be a powerful tool for not only gauging the extent of respiratory problems resulting from COVID-19 and other infectious diseases, but also monitoring improvements or deterioration over longer timescales.
1. Yen S, Preissner M, Bennett E, et al. The Link between Regional Tidal Stretch and Lung Injury during Mechanical Ventilation. Am J Respir Cell Mol Biol. 2018;60(5):569-577. doi:10.1165/rcmb.2018-0143OC
2. Yen S, Preissner M, Bennett E, et al. Interaction between regional lung volumes and ventilator-induced lung injury in the normal and endotoxemic lung. Am J Physiol Lung Cell Mol Physiol. 2020;318(3):L494-L499. doi:10.1152/ajplung.00492.2019
3. Kim EH, Preissner M, Carnibella R, et al. Novel Analysis of 4DCT Imaging Quantifies Progressive Increases in Anatomic Dead Space During Mechanical Ventilation in Mice. J Appl Physiol. Published online June 8, 2017:jap.00903.2016. doi:10.1152/japplphysiol.00903.2016